In reply to gleaney:
A common issue. Could be down to:
1) low battery (cost you a aobut a fiver to replace yourself)
2) static interference (changing your tshirt to cotton can help)
3) radio/ electrical interference (not much you can do about this, except change where you run- this tends to happen in the same place on more or less (not all) occassions.
4) the strap is buggerred.
Garmin HR straps (particularly the 'premium' one) have a very poor failure rate.
Look on the forums on the Garmin website for more info.
If you're worried about your heart,go see a GP.