In reply to Mike Lates:
Seems strange to me, what else but scientific comments would you expect on a thread that starts with linking to a scientific paper?
Anyway, the scepticism voiced here was rather mild. Most natural scientists are extremely cynical about medical publications, because they are often pointing out the bleeding obvious or reveal an allergy of the authors towards maths and the hard sciences.
My favourite is this one from the Journal of Diabetes Care, 1994:
Mary M Tai, MS, EDD : A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves
OBJECTIVE To develop a mathematical model for the determination of total areas under curves from various metabolic studies.
RESEARCH DESIGN AND METHODS In Tai's Model, the total area under a curve is computed by dividing the area under the curve between two designated values on the X-axis (abscissas) into small segments (rectangles and triangles) whose areas can be accurately calculated from their respective geometrical formulas. The total sum of these individual areas thus represents the total area under the curve. Validity of the model is established by comparing total areas obtained from this model to these same areas obtained from graphic method Gess than ±0.4%). Other formulas widely applied by researchers under- or overestimated total area under a metabolic curve by a great margin.
RESULTS Tai's model proves to be able to 1) determine total area under a curve with precision; 2) calculate area with varied shapes that may or may not intercept on one or both X/Y axes; 3) estimate total area under a curve plotted against varied time intervals (abscissas), whereas other formulas only allow the same time interval; and 4) compare total areas of metabolic curves produced by different studies.
CONCLUSIONS The Tai model allows flexibility in experimental conditions, which means, in the case of the glucose-response curve, samples can be taken with differing time intervals and total area under the curve can still be determined with precision.
Embarassing enough that this thing made it through the review process, even worse that it has been cited several hundreds of times!
UKC is also a great community for sharing papers quickly (rather than ordering them via your library if you don´t have immediate access).
When looking up whether I could download a paper someone was looking for, I recently came across the following gem:
Gerold, KB, Cranial gunshot wounds best managed in specialized trauma centers, The Journal of the American Osteopathic Association, May 1991, Vol. 91, 425.
Cheers,
CB