In reply to Ally Smith:
Dominatrix is the one that looms largest in my memory too - it has a "wildness" that the others lack. But one thing to bear in mind is that it would be a pig to work for an extended period. It is quite sparingly bolted with lots of sideways travel up hanging grooves / over roofs - so falls tend to be long and swinging. If you fall off the tricky finish you can end up hanging in free space and unable to regain the rock - so have to descend all the way to the ground and reclimb / dog to strip (not nice when exhausted at the end of the day). Not a problem if you are a quick learner / have a few grades in hand, but I would not enjoy session after session of it.
Biological is probably physically harder, but less intimidating and easier to break down - lots of little hard bits separated by shake-outs (good beta is very helpful). But is is a bit more conditions dependent than Dominatrix - the fingery start is painful and skin-eating in humid weather. Comedy is a short, boulderer's / thugs route and completely unlike any of your other options. Tremelo is a fine route, but not as classic as New Dawn - you will never forget sprinting through the bulges and having a "dark midnight of the soul" trying to get stood on the little ledge.
To be honest though, deliberating about such things will likely be a pointless exercise. In my experience, the routes choose you, not vice versa. Malham / Kilnsey / Gordale suit completely different conditions / times of year - it's no good fixating on New Dawn if you can only visit the area during a very hot spell, when Malham would be a furnace, and working a Gordale or Kilnsey route would be far more enjoyable.