In reply to ksjs: I expect it will cause an increase in quad power and size compared to running. If I spend time doing a lot more running than cycling ( e.g. over the winter) I find my legs are skinnier and I struggle to push bigger gears compared to when I've been cycling more.
The difference isn't particularly large though, and I expect unless you're pushing up steep hills with a low cadence you'll barely notice the difference.
Dependent upon the balance of time running to cycling, you may put on weight in general though - I find it easier and quicker to burn energy running than cycling.