In reply to Mikkel:
I use one in the canoe. The pick and pluck works well, though I suspect it tends to mean you get less in the case than you might expect, and you need to plan it fairly carefully if its for more than one item.
The cases are heavy, but they really are tough, and they really are waterproof (just check the seal is OK every now and then, and there's nothing trapped in it). Mine has been swamped, turned upside down in whitewater spills, and generally abused massively over probably a hundred trips.
They're also quick to open up, hence work well for me in the canoe. I wouldn't like to lug one too far though!
Finally, they make a fantastic occasional table around camp, just the right height for your glass of wine, or freshly brewed coffee, if sat on one of the posh folding chairs like Helinox. Having a canoe means such luxuries are often to hand...