In reply to Derry:
If you are going to North Wales on the M27, M3, A34, M40, M42, M6, M54, A5 route then Didcot Parkway is probably the easiest to drive to, cheaper for your friend, and wont have to get up so early.
If you are going across to the M5 and up the M6 then Chester and take the (quick) A55 to N Wales otherwise there are London trains to Shrewsbury, handy for the A5 approach.