In reply to Removed Userndakota:
Done it many many times from Rotterdam area to the Alps for snowboarding (not climbing). Normally for a 3 day trip. Taking the Friday off. Feels like a proper break, as you get 3 full days snowboarding in my case.
Also done it for the just the weekend, but that's a bit more tiring.
Leave at 2-3 on Thurs afternoon. Drive until 11 ish, up at 6:30 and in a resort for first lift. Having a van helps though, as you can just drive until tired/fed up and them pull over for a proper sleep before continuing. 3 full days, and leave around 2pm on the Sunday.
You will always hit traffic somewhere travelling down on a Thur/Fri evening, but the travel home on a Sunday afternoon can be much easier/quicker.
The key for me was always getting an early finish to set off, plus driving whilst you're getting paid always seems easier.....