In reply to Shapeshifter:
The problem with padding is it spreads your weight from where it should be (your sit bones) to more sensitive areas. Which is fine on a couch as it's spread nice and thinly and you're not moving around, but not so good on a bike.
Where are you finding discomfort? If it's under your sit bones, regular riding will sort it out. If it's elsewhere, the saddle geometry is wrong for you, or you already have too much padding.
As others have said, saddle fit is everything. My touring bike has a lightweight racing saddle with virtually no padding (Specialized Toupe), and is pretty comfy doing 8 hour days in the saddle, as long as I haven't been out of cycling for a while.
I also really rate the ISM Adamo saddle on my tri bike... it was heaven for long distance training in a time trial position after the Toupe (no saddle with a nose will ever be particularly comfortable for that), but would also do a good job on the road bike.