In reply to featuresforfeet:
Did similar with the security anchors my bikes are chained to in the garage.
The hex-head bolts came with ball bearings that are supposed to be hammered in, but I didn't want the permanance of that, so filled the holes with Araldite instead. Pretty hard to get it out with chained bikes in the way, but not too bad if you move the bikes. Glad I did, as brought them with me when we moved house.
Note you'd also need to angle the bike so anything you put in doesn't dribble out before it's set.
Would certainly deter the casual thief, but you could be caught out for a field repair/adjustment.
The anti-theft QRs on my pub bike need a specific tool to undo them and you can get sets that cover the seat post bolt, too. Pretty hard to lock down other expensive components, which is, I guess, what you're thinking of, although the Hexlox stuff is a good start. As a victim of having a saddle and seat post stolen in the past, I sympathise with your plan, anyway. It's tempting to do something like that on my best bike, but I just don't leave that one anywhere out of sight.