In reply to Tonybhoy:
The numbness in your hands will be a nerve - I think it's the ulnar nerve but I am to anatomy as a whale is to boxing. From a cycling perspective it runs across the bony bit on the inside of the heel of your palm. Hence, if you're resting on that a lot, and your bar tape and gloves are thin, then it is likely that you will get numbness. Moving your hands, changing gloves, tape and bar angles can all help (as can awareness).
As far as toes go - that's a combination of the shape of your shoes, the stiffness of the sole and the position of the cleats. No idea which nerve that would be. The following only applies if your have clipless pedals really:
The axle of your pedal should be on the centreline between the widest point of your foot on the outside and the ball of your foot on the inside - adjust the cleat until this is so. The cleat should also be adjusted so that your foot sits in the mid-point of the cleat's play when it is in its natural relaxed position. If when you're pedalling the tension comes up tight to one side before the other, then generally the cleat needs to be shifted to even it up. If your shoes are insufficiently supportive or too tight, that may also do it.
Finally, change your foot position a bit every now and then - a neutral position in the play of your cleats will help in this regard, as will varying you pedal stroke a bit - sit forward more for calves and hamstrings, up/back a bit for quads.
That and focus on a pedalling technique that uses all of the above - think of he motion of a bull pawing the ground, or scraping something nasty off the sole of your shoe. To get the best out of your stroke, pedal strongly using one foot only for five strokes (the other just coasting), then five with the other foot, then 4, 3 and 2. When you've got it nailed with 2 on each side, go for one each side as per normal - your should end up with a powerful almost circular motion that also changes the pressure on the sole of your foot, and happens to make you go faster too