In reply to highcathedral:
Couple of things which may help you narrow the search area.
If you have to drive to London, live somewhere with easy access to the M4 directly. The biggest local motorway traffic issues seem to come between junctions 18 and 19 on the M5 where it crosses the river, and at the intersection between the M4 and M5. You'd save yourself a lot of road-related annoyance if you lived somewhere east of that interchange or with the potential to avoid it..
And if your remote working depends on good internet access, you might want to do some research on who's offering what speeds where. At a recent renegotiation of our broadband/phone/TV package, getting the speeds my wife's employer demanded pretty much meant going with Virgin. Other fibre suppliers may be available elsewhere, but not here.
That might help rule some places out. Were it me looking, I'd start somewhere like Chipping Sodbury. I find the estate lands of Yate very much not to my taste but they may be to yours.
Whilst I like living where I do, south east of Bristol and south west of Bath, should you consider it you should be aware that it takes me 45 minutes to get to any of the M4, M5 or M32 and to get to the M4 you have to go through or round Bath. Nevertheless, you could do worse; nice mix of town and country.
Good luck with your search.
T.