In reply to chockstone:
Having built a few of these and used diamond, square grid and Voronoi tessellation (fancy way to say random) I can safely say none of it matters.
What does matter is marking where the battens on the back go and steering clear of these by a good 25mm. Nothing is more annoying than getting this wrong (well forgetting to fix the T-nut with a screw before you mount the board is about as annoying).
Really don't worry about the grid pattern and if a hold hasn't got a bolt hole just screw it onto the wall with screws wherever you want it.
As soon as you break the virgin surface with your first screw on hold and realise the holds can go where you want it gets a lot easier.
The easiest way to choose the hole pattern it is mark the battens on the front, scatter the required number of tee-nuts over the board and adjust them away from the battens (and to have roughly equal spacing) and drill them where they lay.
Post edited at 18:36